Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway.

نویسندگان

  • Rajarshi Samanta
  • Rishikesh Narayan
  • Jonathan O Bauer
  • Carsten Strohmann
  • Sonja Sievers
  • Andrey P Antonchick
چکیده

A transition metal-free, oxidative, regioselective cross-coupling between non-functionalized azoles and chromones at C2-position was developed. A broad reaction scope and further transformation of products were demonstrated. The biological evaluation of products revealed a novel class of hedgehog signaling pathway inhibitors.

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عنوان ژورنال:
  • Chemical communications

دوره 51 5  شماره 

صفحات  -

تاریخ انتشار 2015